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Hypothyroidism in pregnancy

MedGen UID:
744325
•Concept ID:
C1997262
•
Disease or Syndrome
Synonym: Hypothyroidism in pregnancy, antepartum
SNOMED CT: Hypothyroidism in pregnancy (428165003); Hypothyroidism in pregnancy, antepartum (428165003)

Professional guidelines

PubMed

Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
Lee SY, Pearce EN
Nat Rev Endocrinol 2022 Mar;18(3):158-171. Epub 2022 Jan 4 doi: 10.1038/s41574-021-00604-z. PMID: 34983968Free PMC Article
Subclinical hypothyroidism in pregnancy: controversies on diagnosis and treatment.
Gietka-Czernel M, Glinicki P
Pol Arch Intern Med 2021 Mar 30;131(3):266-275. Epub 2020 Sep 25 doi: 10.20452/pamw.15626. PMID: 32975922
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum.
Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S
Thyroid 2017 Mar;27(3):315-389. doi: 10.1089/thy.2016.0457. PMID: 28056690

Recent clinical studies

Etiology

Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
Lee SY, Pearce EN
Nat Rev Endocrinol 2022 Mar;18(3):158-171. Epub 2022 Jan 4 doi: 10.1038/s41574-021-00604-z. PMID: 34983968Free PMC Article
Subclinical hypothyroidism in pregnancy: controversies on diagnosis and treatment.
Gietka-Czernel M, Glinicki P
Pol Arch Intern Med 2021 Mar 30;131(3):266-275. Epub 2020 Sep 25 doi: 10.20452/pamw.15626. PMID: 32975922
Hypothyroidism in Pregnancy.
Sullivan SA
Clin Obstet Gynecol 2019 Jun;62(2):308-319. doi: 10.1097/GRF.0000000000000432. PMID: 30985406
Thyroid in pregnancy: From physiology to screening.
Springer D, Jiskra J, Limanova Z, Zima T, Potlukova E
Crit Rev Clin Lab Sci 2017 Mar;54(2):102-116. Epub 2017 Jan 19 doi: 10.1080/10408363.2016.1269309. PMID: 28102101
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.
Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM
Thyroid 2016 Apr;26(4):580-90. Epub 2016 Mar 3 doi: 10.1089/thy.2015.0418. PMID: 26837268Free PMC Article

Diagnosis

Thyroid disease in pregnancy.
Yap YW, Onyekwelu E, Alam U
Clin Med (Lond) 2023 Mar;23(2):125-128. doi: 10.7861/clinmed.2023-0018. PMID: 36958843Free PMC Article
Assessment and treatment of thyroid disorders in pregnancy and the postpartum period.
Lee SY, Pearce EN
Nat Rev Endocrinol 2022 Mar;18(3):158-171. Epub 2022 Jan 4 doi: 10.1038/s41574-021-00604-z. PMID: 34983968Free PMC Article
Subclinical hypothyroidism in pregnancy: controversies on diagnosis and treatment.
Gietka-Czernel M, Glinicki P
Pol Arch Intern Med 2021 Mar 30;131(3):266-275. Epub 2020 Sep 25 doi: 10.20452/pamw.15626. PMID: 32975922
Thyroid in pregnancy: From physiology to screening.
Springer D, Jiskra J, Limanova Z, Zima T, Potlukova E
Crit Rev Clin Lab Sci 2017 Mar;54(2):102-116. Epub 2017 Jan 19 doi: 10.1080/10408363.2016.1269309. PMID: 28102101
2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum.
Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S
Thyroid 2017 Mar;27(3):315-389. doi: 10.1089/thy.2016.0457. PMID: 28056690

Therapy

Subclinical hypothyroidism in pregnancy: controversies on diagnosis and treatment.
Gietka-Czernel M, Glinicki P
Pol Arch Intern Med 2021 Mar 30;131(3):266-275. Epub 2020 Sep 25 doi: 10.20452/pamw.15626. PMID: 32975922
Subclinical hypothyroidism in pregnancy.
Toloza FJK, Abedzadeh-Anaraki S, Maraka S
Curr Opin Endocrinol Diabetes Obes 2019 Oct;26(5):225-231. doi: 10.1097/MED.0000000000000491. PMID: 31356254
Hypothyroidism in Pregnancy.
Taylor PN, Lazarus JH
Endocrinol Metab Clin North Am 2019 Sep;48(3):547-556. doi: 10.1016/j.ecl.2019.05.010. PMID: 31345522
Hypothyroidism in Pregnancy.
Sullivan SA
Clin Obstet Gynecol 2019 Jun;62(2):308-319. doi: 10.1097/GRF.0000000000000432. PMID: 30985406
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.
Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM
Thyroid 2016 Apr;26(4):580-90. Epub 2016 Mar 3 doi: 10.1089/thy.2015.0418. PMID: 26837268Free PMC Article

Prognosis

Prevalence, risk factors, and consequences of hypothyroidism among pregnant women in the health region of Lleida: A cohort study.
Siscart J, Perejón D, Serna MC, Oros M, Godoy P, Sole E
PLoS One 2023;18(10):e0278426. Epub 2023 Oct 13 doi: 10.1371/journal.pone.0278426. PMID: 37831694Free PMC Article
Relationship Between Subclinical Hypothyroidism in Pregnancy and Hypertensive Disorder of Pregnancy: A Systematic Review and Meta-Analysis.
Han Y, Wang J, Wang X, Ouyang L, Li Y
Front Endocrinol (Lausanne) 2022;13:823710. Epub 2022 Mar 8 doi: 10.3389/fendo.2022.823710. PMID: 35355565Free PMC Article
Subclinical hypothyroidism in pregnancy.
Toloza FJK, Abedzadeh-Anaraki S, Maraka S
Curr Opin Endocrinol Diabetes Obes 2019 Oct;26(5):225-231. doi: 10.1097/MED.0000000000000491. PMID: 31356254
Thyroid in pregnancy: From physiology to screening.
Springer D, Jiskra J, Limanova Z, Zima T, Potlukova E
Crit Rev Clin Lab Sci 2017 Mar;54(2):102-116. Epub 2017 Jan 19 doi: 10.1080/10408363.2016.1269309. PMID: 28102101
Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity preconception and in pregnancy.
Chan S, Boelaert K
Clin Endocrinol (Oxf) 2015 Mar;82(3):313-26. Epub 2014 Oct 28 doi: 10.1111/cen.12605. PMID: 25200555

Clinical prediction guides

Maternal hypothyroidism and subsequent metabolic outcomes in children: a systematic review and meta-analysis.
Zhao L, Selvaratnam I, Cunningham J, Filion KB, Grandi SM
BMC Pediatr 2024 Aug 1;24(1):490. doi: 10.1186/s12887-024-04963-0. PMID: 39090558Free PMC Article
Subclinical hypothyroidism in pregnancy: controversies on diagnosis and treatment.
Gietka-Czernel M, Glinicki P
Pol Arch Intern Med 2021 Mar 30;131(3):266-275. Epub 2020 Sep 25 doi: 10.20452/pamw.15626. PMID: 32975922
Subclinical hypothyroidism in pregnancy.
Toloza FJK, Abedzadeh-Anaraki S, Maraka S
Curr Opin Endocrinol Diabetes Obes 2019 Oct;26(5):225-231. doi: 10.1097/MED.0000000000000491. PMID: 31356254
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.
Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM
Thyroid 2016 Apr;26(4):580-90. Epub 2016 Mar 3 doi: 10.1089/thy.2015.0418. PMID: 26837268Free PMC Article
Hypothyroidism in pregnancy.
Teng W, Shan Z, Patil-Sisodia K, Cooper DS
Lancet Diabetes Endocrinol 2013 Nov;1(3):228-37. Epub 2013 Oct 18 doi: 10.1016/S2213-8587(13)70109-8. PMID: 24622371

Recent systematic reviews

Maternal hypothyroidism and subsequent metabolic outcomes in children: a systematic review and meta-analysis.
Zhao L, Selvaratnam I, Cunningham J, Filion KB, Grandi SM
BMC Pediatr 2024 Aug 1;24(1):490. doi: 10.1186/s12887-024-04963-0. PMID: 39090558Free PMC Article
Relationship Between Subclinical Hypothyroidism in Pregnancy and Hypertensive Disorder of Pregnancy: A Systematic Review and Meta-Analysis.
Han Y, Wang J, Wang X, Ouyang L, Li Y
Front Endocrinol (Lausanne) 2022;13:823710. Epub 2022 Mar 8 doi: 10.3389/fendo.2022.823710. PMID: 35355565Free PMC Article
Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.
Derakhshan A, Peeters RP, Taylor PN, Bliddal S, Carty DM, Meems M, Vaidya B, Chen L, Knight BA, Ghafoor F, Popova PV, Mosso L, Oken E, Suvanto E, Hisada A, Yoshinaga J, Brown SJ, Bassols J, Auvinen J, Bramer WM, López-Bermejo A, Dayan CM, French R, Boucai L, Vafeiadi M, Grineva EN, Pop VJM, Vrijkotte TG, Chatzi L, Sunyer J, Jiménez-Zabala A, Riaño I, Rebagliato M, Lu X, Pirzada A, Männistö T, Delles C, Feldt-Rasmussen U, Alexander EK, Nelson SM, Chaker L, Pearce EN, Guxens M, Steegers EAP, Walsh JP, Korevaar TIM
Lancet Diabetes Endocrinol 2020 Jun;8(6):501-510. doi: 10.1016/S2213-8587(20)30061-9. PMID: 32445737Free PMC Article
Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis.
Maraka S, Ospina NM, O'Keeffe DT, Espinosa De Ycaza AE, Gionfriddo MR, Erwin PJ, Coddington CC 3rd, Stan MN, Murad MH, Montori VM
Thyroid 2016 Apr;26(4):580-90. Epub 2016 Mar 3 doi: 10.1089/thy.2015.0418. PMID: 26837268Free PMC Article
Interventions for clinical and subclinical hypothyroidism in pregnancy.
Reid SM, Middleton P, Cossich MC, Crowther CA
Cochrane Database Syst Rev 2010 Jul 7;(7):CD007752. doi: 10.1002/14651858.CD007752.pub2. PMID: 20614463

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